Synergistic effect of alcohol & fructose administration on blood urate & biochemical indices of insulin resistance in albino rabbits.

Oral fructose has been shown to reduce the degree and duration of alcohol intoxication by increasing the rate of alcohol elimination from bloodstream. Fructose feeding has also been reported to induce insulin resistance and the resistance is characterized by increase in both blood glucose and triacylglycerol (TAG) levels. We report the synergistic effect of ethanol and fructose administration on the biochemical indicators of insulin resistance (serum glucose and TAG), and the biochemical evidence for ethanol intoxication (serum urate levels) in an experimental study.